Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: insights into a therapeutic strategy for Duchenne muscular …
BJ Jasmin, LM Angus, G Bélanger… - Journal of Physiology …, 2002 - Elsevier
Duchenne muscular dystrophy (DMD) is the most prevalent inherited muscle disease and
results from mutations/deletions in the X-linked dystrophin gene. Although several
approaches have been envisaged to counteract the effects of this progressive disease, there
is currently no cure available. One strategy consists in utilizing a protein normally expressed
in DMD muscle which, once expressed at appropriate levels and at the correct subcellular
location, could compensate for the lack of dystrophin. A candidate for such a role is the …
results from mutations/deletions in the X-linked dystrophin gene. Although several
approaches have been envisaged to counteract the effects of this progressive disease, there
is currently no cure available. One strategy consists in utilizing a protein normally expressed
in DMD muscle which, once expressed at appropriate levels and at the correct subcellular
location, could compensate for the lack of dystrophin. A candidate for such a role is the …
