Nutritional ketosis for weight management and reversal of metabolic syndrome
VM Gershuni, SL Yan, V Medici - Current nutrition reports, 2018 - Springer
VM Gershuni, SL Yan, V Medici
Current nutrition reports, 2018•SpringerAbstract Purpose of Review The goal of this paper is to review current literature on
nutritional ketosis within the context of weight management and metabolic syndrome,
namely, insulin resistance, lipid profile, cardiovascular disease risk, and development of non-
alcoholic fatty liver disease. We provide background on the mechanism of ketogenesis and
describe nutritional ketosis. Recent Findings Nutritional ketosis has been found to improve
metabolic and inflammatory markers, including lipids, HbA1c, high-sensitivity CRP, fasting …
nutritional ketosis within the context of weight management and metabolic syndrome,
namely, insulin resistance, lipid profile, cardiovascular disease risk, and development of non-
alcoholic fatty liver disease. We provide background on the mechanism of ketogenesis and
describe nutritional ketosis. Recent Findings Nutritional ketosis has been found to improve
metabolic and inflammatory markers, including lipids, HbA1c, high-sensitivity CRP, fasting …
Purpose of Review
The goal of this paper is to review current literature on nutritional ketosis within the context of weight management and metabolic syndrome, namely, insulin resistance, lipid profile, cardiovascular disease risk, and development of non-alcoholic fatty liver disease. We provide background on the mechanism of ketogenesis and describe nutritional ketosis.
Recent Findings
Nutritional ketosis has been found to improve metabolic and inflammatory markers, including lipids, HbA1c, high-sensitivity CRP, fasting insulin and glucose levels, and aid in weight management. We discuss these findings and elaborate on potential mechanisms of ketones for promoting weight loss, decreasing hunger, and increasing satiety.
Summary
Humans have evolved with the capacity for metabolic flexibility and the ability to use ketones for fuel. During states of low dietary carbohydrate intake, insulin levels remain low and ketogenesis takes place. These conditions promote breakdown of excess fat stores, sparing of lean muscle, and improvement in insulin sensitivity.
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