Sirolimus steady‐state trough concentrations are not affected by bolus methylprednisolone therapy in renal allograft recipients
L Bäckman, H Kreis, JM Morales… - British journal of …, 2002 - Wiley Online Library
L Bäckman, H Kreis, JM Morales, H Wilczek, R Taylor, JT Burke
British journal of clinical pharmacology, 2002•Wiley Online LibraryAims To determine whether bolus doses of methylprednisolone affect the steady‐state
trough concentrations of sirolimus. Methods Fourteen renal transplant recipients received
concentration‐controlled sirolimus therapy in combination with azathioprine and steroids (n=
8) or mycophenolate mofetil and steroids (n= 6). Bolus doses of methylprednisolone (mean
total dose over 1–5 days, 1694 mg; range, 500–3000 mg) were given for the treatment of
acute rejection. For each patient, the sirolimus dose (mean, 24.1 mg; range, 3.3–52.5 mg) …
trough concentrations of sirolimus. Methods Fourteen renal transplant recipients received
concentration‐controlled sirolimus therapy in combination with azathioprine and steroids (n=
8) or mycophenolate mofetil and steroids (n= 6). Bolus doses of methylprednisolone (mean
total dose over 1–5 days, 1694 mg; range, 500–3000 mg) were given for the treatment of
acute rejection. For each patient, the sirolimus dose (mean, 24.1 mg; range, 3.3–52.5 mg) …
Aims To determine whether bolus doses of methylprednisolone affect the steady‐state trough concentrations of sirolimus.
Methods Fourteen renal transplant recipients received concentration‐controlled sirolimus therapy in combination with azathioprine and steroids (n=8) or mycophenolate mofetil and steroids (n=6). Bolus doses of methylprednisolone (mean total dose over 1–5 days, 1694 mg; range, 500–3000 mg) were given for the treatment of acute rejection. For each patient, the sirolimus dose (mean, 24.1 mg; range, 3.3–52.5 mg) was the same before and during methylprednisolone therapy.
Results Mean sirolimus whole blood trough concentrations before and after treatment with methylprednisolone were 28.8 ng ml−1 (range, 13.9–45.3 ng ml−1), and 28.5 ng ml−1 (range, 13.0–47.9 ng ml−1), respectively (P=0.85; 95% confidence interval on the difference −3.3, 4.0 ng ml−1).
Conclusions Bolus methylprednisolone treatment does not affect steady‐state sirolimus trough concentrations.
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