Design of chimeric antigen receptors with integrated controllable transient functions
A Juillerat, A Marechal, JM Filhol, J Valton, A Duclert… - Scientific reports, 2016 - nature.com
A Juillerat, A Marechal, JM Filhol, J Valton, A Duclert, L Poirot, P Duchateau
Scientific reports, 2016•nature.comThe ability to control T cells engineered to permanently express chimeric antigen receptors
(CARs) is a key feature to improve safety. Here, we describe the development of a new CAR
architecture with an integrated switch-on system that permits to control the CAR T-cell
function. This system offers the advantage of a transient CAR T-cell for safety while letting
open the possibility of multiple cytotoxicity cycles using a small molecule drug.
(CARs) is a key feature to improve safety. Here, we describe the development of a new CAR
architecture with an integrated switch-on system that permits to control the CAR T-cell
function. This system offers the advantage of a transient CAR T-cell for safety while letting
open the possibility of multiple cytotoxicity cycles using a small molecule drug.
Abstract
The ability to control T cells engineered to permanently express chimeric antigen receptors (CARs) is a key feature to improve safety. Here, we describe the development of a new CAR architecture with an integrated switch-on system that permits to control the CAR T-cell function. This system offers the advantage of a transient CAR T-cell for safety while letting open the possibility of multiple cytotoxicity cycles using a small molecule drug.
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