Alpha-actinin in nemaline bodies in congenital nemaline myopathy: immunological confirmation by light and electron microscopy
C Wallgren-Pettersson, B Jasani, GR Newman… - Neuromuscular …, 1995 - Elsevier
To elucidate the protein composition of the nemaline bodies present in the muscle fibres of
patients with congenital nemaline myopathy (CNM), we studied muscle biopsies with
monoclonal antibodies against α-actinin and desmin in combination with a modified Gomori
trichrome method. Electron microscopy of immunolabelled resin embedded sections was
used for cytochemical localisation of a-actinin and desmin. Light microscopy of sections
immunolabelled for a-actinin showed a cross-striation of the muscle fibres corresponding to …
patients with congenital nemaline myopathy (CNM), we studied muscle biopsies with
monoclonal antibodies against α-actinin and desmin in combination with a modified Gomori
trichrome method. Electron microscopy of immunolabelled resin embedded sections was
used for cytochemical localisation of a-actinin and desmin. Light microscopy of sections
immunolabelled for a-actinin showed a cross-striation of the muscle fibres corresponding to …