[HTML][HTML] Control of rapsyn stability by the CUL-3-containing E3 ligase complex
S Nam, K Min, H Hwang, H Lee, JH Lee, J Yoon… - Journal of biological …, 2009 - ASBMB
Rapsyn is a postsynaptic protein required for clustering of nicotinic acetylcholine receptors
(nAChRs) at the neuromuscular junction. Here we report the mechanism for
posttranslational control of rapsyn protein stability. We confirmed that C18H9. 7-encoded
RPY-1 is a rapsyn homolog in Caenorhabditis elegans by showing that human rapsyn
rescued rpy-1 mutant phenotypes in nematodes, as determined by levamisole assays and
micropost array behavioral assays. We found that RPY-1 was degraded in the absence of …
(nAChRs) at the neuromuscular junction. Here we report the mechanism for
posttranslational control of rapsyn protein stability. We confirmed that C18H9. 7-encoded
RPY-1 is a rapsyn homolog in Caenorhabditis elegans by showing that human rapsyn
rescued rpy-1 mutant phenotypes in nematodes, as determined by levamisole assays and
micropost array behavioral assays. We found that RPY-1 was degraded in the absence of …