[HTML][HTML] Small leucine zipper protein (sLZIP) negatively regulates skeletal muscle differentiation via interaction with α-actinin-4
The small leucine zipper protein (sLZIP) plays a role in transcriptional regulation in various
types of cells. However, the role of sLZIP in myogenesis is unknown. We identified α-actinin-
4 (ACTN4) as a sLZIP-binding protein. ACTN4 functions as a transcriptional regulator of
myocyte enhancer factor (MEF) 2, which plays a critical role in expression of muscle-specific
genes during skeletal muscle differentiation. We found that ACTN4 translocates to the
nucleus, induces myogenic gene expression, and promotes myotube formation during …
types of cells. However, the role of sLZIP in myogenesis is unknown. We identified α-actinin-
4 (ACTN4) as a sLZIP-binding protein. ACTN4 functions as a transcriptional regulator of
myocyte enhancer factor (MEF) 2, which plays a critical role in expression of muscle-specific
genes during skeletal muscle differentiation. We found that ACTN4 translocates to the
nucleus, induces myogenic gene expression, and promotes myotube formation during …