[HTML][HTML] Cullin-3–RING ubiquitin ligase activity is required for striated muscle function in mice

JB Papizan, AH Vidal, S Bezprozvannaya… - Journal of Biological …, 2018 - ASBMB
Control of protein homeostasis is an essential cellular process that, when perturbed, can
result in the deregulation or toxic accumulation of proteins. Owing to constant mechanical
stress, striated muscle proteins are particularly prone to wear and tear and require several
protein quality–control mechanisms to coordinate protein turnover and removal of damaged
proteins. Kelch-like proteins, substrate adapters for the Cullin-3 (Cul3)-RING ligase (CRL3)
complex, are emerging as critical regulators of striated muscle development and function …