[HTML][HTML] Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells
G Bakdash, LTC Vogelpoel, TM Van Capel… - Mucosal …, 2015 - Elsevier
The vitamin A metabolite all-trans retinoic acid (RA) is an important determinant of intestinal
immunity. RA primes dendritic cells (DCs) to express CD103 and produce RA themselves,
which induces the gut-homing receptors α4β7 and CCR9 on T cells and amplifies
transforming growth factor (TGF)-β-mediated development of Foxp3+ regulatory T (Treg)
cells. Here we investigated the effect of RA on human DCs and subsequent development of
T cells. We report a novel role of RA in immune regulation by showing that RA-conditioned …
immunity. RA primes dendritic cells (DCs) to express CD103 and produce RA themselves,
which induces the gut-homing receptors α4β7 and CCR9 on T cells and amplifies
transforming growth factor (TGF)-β-mediated development of Foxp3+ regulatory T (Treg)
cells. Here we investigated the effect of RA on human DCs and subsequent development of
T cells. We report a novel role of RA in immune regulation by showing that RA-conditioned …