Clinical trials for severe sepsis: past failures, and future hopes
SM Opal, AS Cross - Infectious disease clinics of North America, 1999 - Elsevier
Since the original preliminary success with J5 antisera in the treatment of septic shock in
1982, 57 the field of clinical sepsis research has suffered a long series of failed clinical trials
that studied new treatment strategies for septic shock. Over 13,000 patients have been
enrolled in at least 23 multicenter, double-blind, placebo-controlled, clinical trials in an
attempt to develop new treatments for septic shock. 38, 55 Unfortunately, the results have
been generally disappointing and interspersed with some spectacular failures and …
1982, 57 the field of clinical sepsis research has suffered a long series of failed clinical trials
that studied new treatment strategies for septic shock. Over 13,000 patients have been
enrolled in at least 23 multicenter, double-blind, placebo-controlled, clinical trials in an
attempt to develop new treatments for septic shock. 38, 55 Unfortunately, the results have
been generally disappointing and interspersed with some spectacular failures and …
