[HTML][HTML] Estrogen receptor (ER) α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression

BG Drew, H Hamidi, Z Zhou, CJ Villanueva… - Journal of Biological …, 2015 - ASBMB
Obesity is associated with increased breast cancer (BrCA) incidence. Considering that
inactivation of estrogen receptor (ER) α promotes obesity and metabolic dysfunction in
women and female mice, understanding the mechanisms and tissue-specific sites of ERα
action to combat metabolic-related disease, including BrCA, is of clinical importance. To
study the role of ERα in adipose tissue we generated fat-specific ERα knock-out (FERKO)
mice. Herein we show that ERα deletion increased adipocyte size, fat pad weight, and tissue …