[HTML][HTML] Transcriptional control of brown adipocyte development and physiological function—of mice and men
P Seale, S Kajimura, BM Spiegelman - Genes & development, 2009 - genesdev.cshlp.org
P Seale, S Kajimura, BM Spiegelman
Genes & development, 2009•genesdev.cshlp.orgThe last several years have seen an explosion of information relating to the transcriptional
control of brown fat cell development. At the same time, new data have emerged that clearly
demonstrate that adult humans do indeed have substantial amounts of functioning brown
adipose tissue (BAT). Together, these advances are stimulating a reassessment of the role
of brown adipose tissue in human physiology and pathophysiology. These data have also
opened up exciting new opportunities for the development of entirely novel classes of …
control of brown fat cell development. At the same time, new data have emerged that clearly
demonstrate that adult humans do indeed have substantial amounts of functioning brown
adipose tissue (BAT). Together, these advances are stimulating a reassessment of the role
of brown adipose tissue in human physiology and pathophysiology. These data have also
opened up exciting new opportunities for the development of entirely novel classes of …
Abstract
The last several years have seen an explosion of information relating to the transcriptional control of brown fat cell development. At the same time, new data have emerged that clearly demonstrate that adult humans do indeed have substantial amounts of functioning brown adipose tissue (BAT). Together, these advances are stimulating a reassessment of the role of brown adipose tissue in human physiology and pathophysiology. These data have also opened up exciting new opportunities for the development of entirely novel classes of therapeutics for metabolic diseases like obesity and type 2 diabetes.
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