Proton pump inhibitors and risk of incident CKD and progression to ESRD
The association between proton pump inhibitors (PPI) use and risk of acute interstitial
nephritis has been described. However, whether exposure to PPI associates with incident
CKD, CKD progression, or ESRD is not known. We used Department of Veterans Affairs
national databases to build a primary cohort of new users of PPI (n= 173,321) and new
users of histamine H 2-receptor antagonists (H 2 blockers; n= 20,270) and followed these
patients over 5 years to ascertain renal outcomes. In adjusted Cox survival models, the PPI …
nephritis has been described. However, whether exposure to PPI associates with incident
CKD, CKD progression, or ESRD is not known. We used Department of Veterans Affairs
national databases to build a primary cohort of new users of PPI (n= 173,321) and new
users of histamine H 2-receptor antagonists (H 2 blockers; n= 20,270) and followed these
patients over 5 years to ascertain renal outcomes. In adjusted Cox survival models, the PPI …