[PDF][PDF] Evolution of mitochondria as signaling organelles
NS Chandel - Cell metabolism, 2015 - cell.com
Cell metabolism, 2015•cell.com
Mitochondria have primarily been viewed as bioenergetic and biosynthetic organelles that
autonomously co-exist within the cell. However, the past two decades have provided
evidence that mitochondria function as signaling organelles, constantly communicating with
the cytosol to initiate biological events under homeostatic and stress conditions. Thus, the
signaling function of the mitochondria may have been selected by nature from the inception
of the early eukaryote, as discussed in this essay.
autonomously co-exist within the cell. However, the past two decades have provided
evidence that mitochondria function as signaling organelles, constantly communicating with
the cytosol to initiate biological events under homeostatic and stress conditions. Thus, the
signaling function of the mitochondria may have been selected by nature from the inception
of the early eukaryote, as discussed in this essay.
Mitochondria have primarily been viewed as bioenergetic and biosynthetic organelles that autonomously co-exist within the cell. However, the past two decades have provided evidence that mitochondria function as signaling organelles, constantly communicating with the cytosol to initiate biological events under homeostatic and stress conditions. Thus, the signaling function of the mitochondria may have been selected by nature from the inception of the early eukaryote, as discussed in this essay.
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