Evaluation of phagocytosis and arachidonate metabolism by alveolar macrophages and recruited neutrophils from F344xBN rats of different ages
P Mancuso, RW McNish, M Peters-Golden… - Mechanisms of ageing …, 2001 - Elsevier
The incidence of infectious respiratory diseases increases with aging. Resident alveolar
macrophages (AMs) and recruited leukocytes (PMNL) mediate cellular defense against
bacterial infections in the lung, and phagocytosis and lipid mediator synthesis are important
components of their antimicrobial capacity. The objective of this study was to determine if
either phagocytic capacity or lipid mediator generation declines with normal aging, in either
AMs or PMNL recruited to a site of inflammation. The F344xBN rat hybrid has a lower …
macrophages (AMs) and recruited leukocytes (PMNL) mediate cellular defense against
bacterial infections in the lung, and phagocytosis and lipid mediator synthesis are important
components of their antimicrobial capacity. The objective of this study was to determine if
either phagocytic capacity or lipid mediator generation declines with normal aging, in either
AMs or PMNL recruited to a site of inflammation. The F344xBN rat hybrid has a lower …
