[PDF][PDF] Hematopoiesis: reconciling historic controversies about the niche
N Baryawno, N Severe, DT Scadden - Cell Stem Cell, 2017 - cell.com
N Baryawno, N Severe, DT Scadden
Cell Stem Cell, 2017•cell.comThe niche, as first conceptualized, was in conflict with the prevailing wisdom that stem cells
have internal logic. The niche hypothesis has been indisputably confirmed. Yet, recent
findings indicate little plasticity of epigenetically scripted hematopoietic stem/progenitors.
Reconciling this conflict requires re-envisioning the niche as an enabler, not designer, of cell
fate.
have internal logic. The niche hypothesis has been indisputably confirmed. Yet, recent
findings indicate little plasticity of epigenetically scripted hematopoietic stem/progenitors.
Reconciling this conflict requires re-envisioning the niche as an enabler, not designer, of cell
fate.
The niche, as first conceptualized, was in conflict with the prevailing wisdom that stem cells have internal logic. The niche hypothesis has been indisputably confirmed. Yet, recent findings indicate little plasticity of epigenetically scripted hematopoietic stem/progenitors. Reconciling this conflict requires re-envisioning the niche as an enabler, not designer, of cell fate.
cell.com