[HTML][HTML] The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic α-cells
N Quoix, R Cheng-Xue, Y Guiot, PL Herrera… - FEBS letters, 2007 - Elsevier
N Quoix, R Cheng-Xue, Y Guiot, PL Herrera, JC Henquin, P Gilon
FEBS letters, 2007•ElsevierThe control of glucagon secretion by pancreatic α-cells is poorly understood, largely
because of the difficulty to recognize living α-cells. We describe a new mouse model,
referred to as GluCre-ROSA26EYFP (or GYY), allowing easy α-cell identification because of
specific expression of EYFP. GYY mice displayed normal glycemic control during a
fasting/refeeding test or intraperitoneal insulin injection. Glucagon secretion by isolated
islets was normally inhibited by glucose and stimulated by adrenaline.[Ca2+] c responses to …
because of the difficulty to recognize living α-cells. We describe a new mouse model,
referred to as GluCre-ROSA26EYFP (or GYY), allowing easy α-cell identification because of
specific expression of EYFP. GYY mice displayed normal glycemic control during a
fasting/refeeding test or intraperitoneal insulin injection. Glucagon secretion by isolated
islets was normally inhibited by glucose and stimulated by adrenaline.[Ca2+] c responses to …
The control of glucagon secretion by pancreatic α-cells is poorly understood, largely because of the difficulty to recognize living α-cells. We describe a new mouse model, referred to as GluCre-ROSA26EYFP (or GYY), allowing easy α-cell identification because of specific expression of EYFP. GYY mice displayed normal glycemic control during a fasting/refeeding test or intraperitoneal insulin injection. Glucagon secretion by isolated islets was normally inhibited by glucose and stimulated by adrenaline. [Ca2+]c responses to arginine, adrenaline, diazoxide and tolbutamide, were similar in GYY and control mice. Hence, this new mouse model is a reliable and powerful tool to specifically study α-cells.
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