[HTML][HTML] Adipose tissue remodeling and obesity

K Sun, CM Kusminski, PE Scherer - The Journal of clinical …, 2011 - Am Soc Clin Investig
K Sun, CM Kusminski, PE Scherer
The Journal of clinical investigation, 2011Am Soc Clin Investig
To fulfill its role as the major energy-storing tissue, adipose has several unique properties
that cannot be seen in any other organ, including an almost unlimited capacity to expand in
a non-transformed state. As such, the tissue requires potent mechanisms to remodel, acutely
and chronically. Adipocytes can rapidly reach the diffusional limit of oxygen during growth;
hypoxia is therefore an early determinant that limits healthy expansion. Proper expansion
requires a highly coordinated response among many different cell types, including …
To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. As such, the tissue requires potent mechanisms to remodel, acutely and chronically. Adipocytes can rapidly reach the diffusional limit of oxygen during growth; hypoxia is therefore an early determinant that limits healthy expansion. Proper expansion requires a highly coordinated response among many different cell types, including endothelial precursor cells, immune cells, and preadipocytes. There are therefore remarkable similarities between adipose expansion and growth of solid tumors, a phenomenon that presents both an opportunity and a challenge, since pharmacological interventions supporting healthy adipose tissue adaptation can also facilitate tumor growth.
The Journal of Clinical Investigation