Metabolic control of myofibers: promising therapeutic target for obesity and type 2 diabetes
Y Duan, F Li, B Tan, K Yao, Y Yin - Obesity reviews, 2017 - Wiley Online Library
Y Duan, F Li, B Tan, K Yao, Y Yin
Obesity reviews, 2017•Wiley Online LibraryMammalian skeletal muscles are composed of two major fibre types (I and II) that differ in
terms of size, metabolism and contractile properties. In general, slow‐twitch type I fibres are
rich in mitochondria and have a greater insulin sensitivity than fast‐twitch type II skeletal
muscles. Although not widely appreciated, a forced induction of the slow skeletal muscle
phenotype may inhibit the progress of obesity and diabetes. This potentially forms the basis
for targeting slow/oxidative myofibers in the treatment of obesity. In this context, a better …
terms of size, metabolism and contractile properties. In general, slow‐twitch type I fibres are
rich in mitochondria and have a greater insulin sensitivity than fast‐twitch type II skeletal
muscles. Although not widely appreciated, a forced induction of the slow skeletal muscle
phenotype may inhibit the progress of obesity and diabetes. This potentially forms the basis
for targeting slow/oxidative myofibers in the treatment of obesity. In this context, a better …
Summary
Mammalian skeletal muscles are composed of two major fibre types (I and II) that differ in terms of size, metabolism and contractile properties. In general, slow‐twitch type I fibres are rich in mitochondria and have a greater insulin sensitivity than fast‐twitch type II skeletal muscles. Although not widely appreciated, a forced induction of the slow skeletal muscle phenotype may inhibit the progress of obesity and diabetes. This potentially forms the basis for targeting slow/oxidative myofibers in the treatment of obesity. In this context, a better understanding of the molecular basis of fibre‐type specification and plasticity may help to identify potential therapeutic targets for obesity and diabetes.
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