Persistent over-expression of specific CC class chemokines correlates with macrophage and T-cell recruitment in mdx skeletal muscle
JD Porter, W Guo, AP Merriam, S Khanna… - Neuromuscular …, 2003 - Elsevier
Prior studies and the efficacy of immunotherapies provide evidence that inflammation is
mechanistic in pathogenesis of Duchenne muscular dystrophy. To identify putative pro-
inflammatory mechanisms, we evaluated chemokine gene/protein expression patterns in
skeletal muscle of mdx mice. By DNA microarray, reverse transcription-polymerase chain
reaction, quantitative polymerase chain reaction, and immunoblotting, convergent evidence
established the induction of six distinct CC class chemokine ligands in adult mdx …
mechanistic in pathogenesis of Duchenne muscular dystrophy. To identify putative pro-
inflammatory mechanisms, we evaluated chemokine gene/protein expression patterns in
skeletal muscle of mdx mice. By DNA microarray, reverse transcription-polymerase chain
reaction, quantitative polymerase chain reaction, and immunoblotting, convergent evidence
established the induction of six distinct CC class chemokine ligands in adult mdx …