Association of MUC16 mutation with tumor mutation load and outcomes in patients with gastric cancer
Importance MUC16, which encodes cancer antigen 125 (CA-125), is frequently mutated in
gastric cancer (GC); however, its association with tumor mutation load (TML) and outcome in
patients with GC has not been established, to date. Objective To investigate
whetherMUC16mutations are associated with TML and prognosis in patients with GC.
Design, Setting, and Participants Statistical analysis of genomic data from 437 GC samples
obtained from The Cancer Genome Atlas (TCGA) and 256 samples from an Asian cohort …
gastric cancer (GC); however, its association with tumor mutation load (TML) and outcome in
patients with GC has not been established, to date. Objective To investigate
whetherMUC16mutations are associated with TML and prognosis in patients with GC.
Design, Setting, and Participants Statistical analysis of genomic data from 437 GC samples
obtained from The Cancer Genome Atlas (TCGA) and 256 samples from an Asian cohort …