[HTML][HTML] Foxp3: a critical regulator of the development and function of regulatory T cells
S Hori, S Sakaguchi - Microbes and infection, 2004 - Elsevier
Regulatory T cells are capable of suppressing deleterious immune responses against self-or
non-self-antigens. Their essential role in tolerance and immune regulation has been
illustrated by recent findings that mutations in the Foxp3 gene leads to the defective
development of regulatory T cells and the emergence of a fatal autoimmune, inflammatory
and allergic disease. This review discusses the critical role for this transcription factor in the
development and function of regulatory T cells.
non-self-antigens. Their essential role in tolerance and immune regulation has been
illustrated by recent findings that mutations in the Foxp3 gene leads to the defective
development of regulatory T cells and the emergence of a fatal autoimmune, inflammatory
and allergic disease. This review discusses the critical role for this transcription factor in the
development and function of regulatory T cells.