[HTML][HTML] Tumor necrosis factor-α (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways
YH Zhang, A Heulsmann, MM Tondravi… - Journal of Biological …, 2001 - ASBMB
Tumor necrosis factor-α (TNF) and the ligand for receptor activator of NF-κB (RANKL) are
abundant in sites of inflammatory bone erosion. Because these cytokines are potent
osteoclastogenic factors and because their signaling pathways are considerably
overlapping, we postulated that under pro-inflammatory conditions RANKL and TNF might
synergistically orchestrate enhanced osteoclastogenesis via cooperative mechanisms. We
found TNF, via TNF type 1 receptor (TNFr1), prompts robust osteoclastogenesis by …
abundant in sites of inflammatory bone erosion. Because these cytokines are potent
osteoclastogenic factors and because their signaling pathways are considerably
overlapping, we postulated that under pro-inflammatory conditions RANKL and TNF might
synergistically orchestrate enhanced osteoclastogenesis via cooperative mechanisms. We
found TNF, via TNF type 1 receptor (TNFr1), prompts robust osteoclastogenesis by …