[HTML][HTML] Lipooligosaccharide of Campylobacter jejuni: similarity with multiple types of mammalian glycans beyond gangliosides
RS Houliston, E Vinogradov, M Dzieciatkowska… - Journal of biological …, 2011 - ASBMB
Campylobacter jejuni is well known for synthesizing ganglioside mimics within the glycan
component of its lipooligosaccharide (LOS), which have been implicated in triggering
Guillain-Barré syndrome. We now confirm that this pathogen is capable of synthesizing a
much broader spectrum of host glycolipid/glycoprotein mimics within its LOS. P blood group
and paragloboside (lacto-N-neotetraose) antigen mimicry is exhibited by RM1221, a strain
isolated from a poultry source. RM1503, a gastroenteritis-associated strain, expresses lacto …
component of its lipooligosaccharide (LOS), which have been implicated in triggering
Guillain-Barré syndrome. We now confirm that this pathogen is capable of synthesizing a
much broader spectrum of host glycolipid/glycoprotein mimics within its LOS. P blood group
and paragloboside (lacto-N-neotetraose) antigen mimicry is exhibited by RM1221, a strain
isolated from a poultry source. RM1503, a gastroenteritis-associated strain, expresses lacto …