Aging is a key risk factor associated with the onset of cardiovascular disease. Notably,
vascular aging and cardiovascular disease are both associated with endothelial dysfunction,
or a marked decrease in production and bioavailability the vasodilator of nitric oxide (NO).
As a result of decreased nitric oxide availability, aging vessels often exhibit endothelial cell
senescence and increased oxidative stress. One of the most potent activators of NO
production is fluid shear stress produced by blood flow. Interestingly, age-related decrease …