[HTML][HTML] Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation
KD Salpea, PJ Talmud, JA Cooper, CG Maubaret… - Atherosclerosis, 2010 - Elsevier
OBJECTIVE: High oxidative stress potentially leads to accelerated telomere shortening and
consequent premature cell senescence, implicated in type 2 diabetes (T2D) development.
Therefore, we studied the association of leukocyte telomere length (LTL) with the presence
of T2D, as well as the effect on the patients' LTL of plasma oxidative stress and of variation in
UCP2, a gene involved in the mitochondrial production of reactive oxygen species.
METHODS: Mean LTL was determined in 569 Caucasian, 103 South Asian and 70 Afro …
consequent premature cell senescence, implicated in type 2 diabetes (T2D) development.
Therefore, we studied the association of leukocyte telomere length (LTL) with the presence
of T2D, as well as the effect on the patients' LTL of plasma oxidative stress and of variation in
UCP2, a gene involved in the mitochondrial production of reactive oxygen species.
METHODS: Mean LTL was determined in 569 Caucasian, 103 South Asian and 70 Afro …