Accumulation of memory T cells from childhood to old age: central and effector memory cells in CD4+ versus effector memory and terminally differentiated memory …
P Saule, J Trauet, V Dutriez, V Lekeux… - Mechanisms of ageing …, 2006 - Elsevier
Memory T cells can be classified as central memory (TCM, CD45RAnegCCR7+), effector
memory (TEM, CD45RAnegCCR7neg), and terminally differentiated cells (TTD, CD45RA+
CCR7neg) with different homing and effector capacities. In 101 healthy subjects aged from 5
to 96 years, distinct dynamics were evidenced between circulating CD4+ and CD8+ T cell
populations. Naive CD4+ and CD8+ T cells decreased linearly with age, CD8+ twice more
rapidly. Memory cells outnumbered naive cells on average at 37.4 in the CD4+ and 29.5 …
memory (TEM, CD45RAnegCCR7neg), and terminally differentiated cells (TTD, CD45RA+
CCR7neg) with different homing and effector capacities. In 101 healthy subjects aged from 5
to 96 years, distinct dynamics were evidenced between circulating CD4+ and CD8+ T cell
populations. Naive CD4+ and CD8+ T cells decreased linearly with age, CD8+ twice more
rapidly. Memory cells outnumbered naive cells on average at 37.4 in the CD4+ and 29.5 …