CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory
CD4+ and CD8+ peripheral blood T lymphocytes show mutually exclusive expression of
CD45RA or CD45R0, two isoforms of the common leukocyte antigen that seem to recognize
so-called virgin/unprimed and memory/activated T cells. The expression of these isoforms
has been studied by three colour cytofluorimetric analysis on CD4+ or CD8+ peripheral
blood CD3+ cells from 22 healthy centenarians, analyzed in a context of 202 healthy donors
0–110 years old. An age-related unbalance of virgin and memory cells was found between …
CD45RA or CD45R0, two isoforms of the common leukocyte antigen that seem to recognize
so-called virgin/unprimed and memory/activated T cells. The expression of these isoforms
has been studied by three colour cytofluorimetric analysis on CD4+ or CD8+ peripheral
blood CD3+ cells from 22 healthy centenarians, analyzed in a context of 202 healthy donors
0–110 years old. An age-related unbalance of virgin and memory cells was found between …