[HTML][HTML] Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis
PJ Fernandez-Marcos, J Auwerx - The American journal of clinical nutrition, 2011 - Elsevier
Mechanisms responsible for energy management in the cell and in the whole organism
require a complex network of transcription factors and cofactors. Peroxisome proliferator-
activated receptor γ coactivator 1α (PGC-1α) has emerged as a master regulator of
mitochondrial biogenesis and function, thus becoming a crucial metabolic node. We present
an overview of the mechanisms by which PGC-1α is regulated, including the transcriptional
regulation of PGC-1α expression and the fine-tuning of its final activity via posttranslational …
require a complex network of transcription factors and cofactors. Peroxisome proliferator-
activated receptor γ coactivator 1α (PGC-1α) has emerged as a master regulator of
mitochondrial biogenesis and function, thus becoming a crucial metabolic node. We present
an overview of the mechanisms by which PGC-1α is regulated, including the transcriptional
regulation of PGC-1α expression and the fine-tuning of its final activity via posttranslational …