Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging
JJ Lemasters - Rejuvenation research, 2005 - liebertpub.com
Rejuvenation research, 2005•liebertpub.com
In autophagy, portions of cytoplasm are sequestered into autophagosomes and delivered to
lysosomes for degradation. Long assumed to be a random process, increasing evidence
suggests that autophagy of mitochondria, peroxisomes, and possibly other organelles is
selective. A recent paper (Kissova et al., J. Biol. Chem. 2004; 279: 39068–39074) shows in
yeast that a specific outer membrane protein, Uth1p, is required for efficient mitochondrial
autophagy. For this selective autophagy of mitochondria, we propose the term" mitophagy" …
lysosomes for degradation. Long assumed to be a random process, increasing evidence
suggests that autophagy of mitochondria, peroxisomes, and possibly other organelles is
selective. A recent paper (Kissova et al., J. Biol. Chem. 2004; 279: 39068–39074) shows in
yeast that a specific outer membrane protein, Uth1p, is required for efficient mitochondrial
autophagy. For this selective autophagy of mitochondria, we propose the term" mitophagy" …
In autophagy, portions of cytoplasm are sequestered into autophagosomes and delivered to lysosomes for degradation. Long assumed to be a random process, increasing evidence suggests that autophagy of mitochondria, peroxisomes, and possibly other organelles is selective. A recent paper (Kissova et al., J. Biol. Chem. 2004;279:39068–39074) shows in yeast that a specific outer membrane protein, Uth1p, is required for efficient mitochondrial autophagy. For this selective autophagy of mitochondria, we propose the term "mitophagy" to emphasize the non-random nature of the process. Mitophagy may play a key role in retarding accumulation of somatic mutations of mtDNA with aging.
Mary Ann Liebert