[HTML][HTML] High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy

LC Gomes, L Scorrano - Biochimica et Biophysica Acta (BBA) …, 2008 - Elsevier
LC Gomes, L Scorrano
Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2008Elsevier
Damaged mitochondria can be eliminated in a process of organelle autophagy, termed
mitophagy. In most cells, the organization of mitochondria in a network could interfere with
the selective elimination of damaged ones. In principle, fission of this network should
precede mitophagy; but it is unclear whether it is per se a trigger of autophagy. The pro-
fission mitochondrial protein Fis1 induced mitochondrial fragmentation and enhanced the
formation of autophagosomes which could enclose mitochondria. These changes correlated …
Damaged mitochondria can be eliminated in a process of organelle autophagy, termed mitophagy. In most cells, the organization of mitochondria in a network could interfere with the selective elimination of damaged ones. In principle, fission of this network should precede mitophagy; but it is unclear whether it is per se a trigger of autophagy. The pro-fission mitochondrial protein Fis1 induced mitochondrial fragmentation and enhanced the formation of autophagosomes which could enclose mitochondria. These changes correlated with mitochondrial dysfunction rather than with fragmentation, as substantiated by Fis1 mutants with different effects on organelle shape and function. In conclusion, fission associated with mitochondrial dysfunction stimulates an increase in autophagy.
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