Fibroblasts and myofibroblasts of the intestinal lamina propria in physiology and disease

M Roulis, RA Flavell - Differentiation, 2016 - Elsevier
In this Review we summarize our current understanding of the biology of mesenchymal cells
of the intestinal lamina propria focusing mainly on fibroblasts and myofibroblasts. The topics
covered include 1) the embryonic origin of mesenchymal cells of the intestinal lamina
propria and their heterogeneity in adults, 2) the role of the mesenchyme in intestinal
development, 3) the physiological function of fibroblasts and myofibroblasts in adults as part
of the intestinal stem cell niche and the mucosal immune system and 4) the involvement of …