Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation
C Liu, SJ Wilson, C Kuei, TW Lovenberg - The Journal of pharmacology …, 2001 - Elsevier
The recently identified histamine H 4 receptor has revealed a potential new complexity for
the role of histamine in the immune system. To begin to understand the role of this receptor
in humans, one must first determine whether homologs exist and can be studied in lower
species. To address this, we cloned the rat, mouse, and guinea pig cDNAs corresponding to
the recently identified human histamine H 4 receptor. The rat, mouse, and guinea pig H 4
sequences are significantly different from the human H 4 sequence at 69, 68, and 65 …
the role of histamine in the immune system. To begin to understand the role of this receptor
in humans, one must first determine whether homologs exist and can be studied in lower
species. To address this, we cloned the rat, mouse, and guinea pig cDNAs corresponding to
the recently identified human histamine H 4 receptor. The rat, mouse, and guinea pig H 4
sequences are significantly different from the human H 4 sequence at 69, 68, and 65 …