Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond
AA Pendse, JM Arbones-Mainar, LA Johnson… - Journal of lipid …, 2009 - jlr.org
Given the multiple differences between mice and men, it was once thought that mice could
not be used to model atherosclerosis, principally a human disease. Apolipoprotein E-
deficient (apoEKO) mice have convincingly changed this view, and the ability to model
human-like plaques in these mice has provided scientists a platform to study multiple facets
of atherogenesis and to explore potential therapeutic interventions. In addition to its well-
established role in lipoprotein metabolism, recent observations of reduced adiposity and …
not be used to model atherosclerosis, principally a human disease. Apolipoprotein E-
deficient (apoEKO) mice have convincingly changed this view, and the ability to model
human-like plaques in these mice has provided scientists a platform to study multiple facets
of atherogenesis and to explore potential therapeutic interventions. In addition to its well-
established role in lipoprotein metabolism, recent observations of reduced adiposity and …
