Small molecule inhibitors of many classes of enzymes, including phosphatases, have
widespread use as experimental tools and as therapeutics. Efforts to develop inhibitors
against the lipid phosphatase and tumour suppressor, PTEN, was for some time limited by
concerns that their use as therapy could result in increased risk of cancer. However, the
accumulation of evidence that short term PTEN inhibition may be valuable in conditions
such as nerve injury has raised interest. Here we investigate the inhibition of PTEN by four …