Type I interferons are associated with lupus. Genes that are regulated by IFN-α are
upregulated in pediatric lupus patients. Gene deletion of the IFN-α/β receptor in
experimental lupus-like NZB mice results in reduced disease activity. Conversely, IFN-β is a
well-established treatment in multiple sclerosis, another autoimmune disease. For
determining whether IFN-β treatment is harmful or beneficial in lupus, MRL-Fas lpr mice
were injected with this type I IFN. Treatment was initiated in MRL-Fas lpr mice with mild and …