Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens
BAC Cree, CM Spencer, M Varrin‐Doyer… - Annals of …, 2016 - Wiley Online Library
Annals of neurology, 2016•Wiley Online Library
T cells from neuromyelitis optica (NMO) patients, which recognize the immunodominant
epitope of aquaporin‐4, exhibit Th17 polarization and cross‐react with a homologous
sequence of a Clostridium perfringens adenosine triphosphate‐binding cassette transporter.
Therefore, this commensal microbe might participate in NMO pathogenesis. We examined
the gut microbiome by PhyloChip G3 from 16 NMO patients, 16 healthy controls (HC), and
16 multiple sclerosis patients. A significant difference in the abundance of several microbial …
epitope of aquaporin‐4, exhibit Th17 polarization and cross‐react with a homologous
sequence of a Clostridium perfringens adenosine triphosphate‐binding cassette transporter.
Therefore, this commensal microbe might participate in NMO pathogenesis. We examined
the gut microbiome by PhyloChip G3 from 16 NMO patients, 16 healthy controls (HC), and
16 multiple sclerosis patients. A significant difference in the abundance of several microbial …
T cells from neuromyelitis optica (NMO) patients, which recognize the immunodominant epitope of aquaporin‐4, exhibit Th17 polarization and cross‐react with a homologous sequence of a Clostridium perfringens adenosine triphosphate‐binding cassette transporter. Therefore, this commensal microbe might participate in NMO pathogenesis. We examined the gut microbiome by PhyloChip G3 from 16 NMO patients, 16 healthy controls (HC), and 16 multiple sclerosis patients. A significant difference in the abundance of several microbial communities was observed between NMO and HC (Adonis test, p = 0.001). Strikingly, C. perfringens was overrepresented in NMO (p = 5.24 × 10−8). These observations support a potential role for C. perfringens in NMO pathogenesis. Ann Neurol 2016;80:443–447
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