SOCS regulation of the JAK/STAT signalling pathway
BA Croker, H Kiu, SE Nicholson - Seminars in cell & developmental biology, 2008 - Elsevier
BA Croker, H Kiu, SE Nicholson
Seminars in cell & developmental biology, 2008•ElsevierThe suppressor of cytokine signalling (SOCS) proteins were, as their name suggests, first
described as inhibitors of cytokine signalling. While their actions clearly now extend to other
intracellular pathways, they remain key negative regulators of cytokine and growth factor
signalling. In this review we focus on the mechanics of SOCS action and the complexities of
the mouse models that have underpinned our current understanding of SOCS biology.
described as inhibitors of cytokine signalling. While their actions clearly now extend to other
intracellular pathways, they remain key negative regulators of cytokine and growth factor
signalling. In this review we focus on the mechanics of SOCS action and the complexities of
the mouse models that have underpinned our current understanding of SOCS biology.
The suppressor of cytokine signalling (SOCS) proteins were, as their name suggests, first described as inhibitors of cytokine signalling. While their actions clearly now extend to other intracellular pathways, they remain key negative regulators of cytokine and growth factor signalling. In this review we focus on the mechanics of SOCS action and the complexities of the mouse models that have underpinned our current understanding of SOCS biology.
Elsevier