[HTML][HTML] Pseudomonas aeruginosa induced airway epithelial injury drives fibroblast activation: a mechanism in chronic lung allograft dysfunction

LA Borthwick, MI Suwara, SC Carnell, NJ Green… - American Journal of …, 2016 - Elsevier
Bacterial infections after lung transplantation cause airway epithelial injury and are
associated with an increased risk of developing bronchiolitis obliterans syndrome. The
damaged epithelium is a source of alarmins that activate the innate immune system, yet their
ability to activate fibroblasts in the development of bronchiolitis obliterans syndrome has not
been evaluated. Two epithelial alarmins were measured longitudinally in bronchoalveolar
lavages from lung transplant recipients who developed bronchiolitis obliterans syndrome …