[PDF][PDF] Cutting edge: CD4 CD25 alloantigen-specific immunoregulatory cells that can prevent CD8 T cell-mediated graft rejection: implications for anti-CD154 …
A van Maurik, M Herber, KJ Wood, ND Jones - J. Immunol, 2002 - researchgate.net
A van Maurik, M Herber, KJ Wood, ND Jones
J. Immunol, 2002•researchgate.netBlockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in
selected rodent and in primate models, but, due to the ability of CD154-independent CD8+ T
cells to initiate graft rejection, this strategy is not always effective. In this work we
demonstrate that blockade of the CD40-CD154 pathway at the time of transplantation
enables the generation of donor alloantigen-specific CD4+ CD25+ regulatory T cells, and
that if the regulatory cells are present in sufficient numbers they can suppress allograft …
selected rodent and in primate models, but, due to the ability of CD154-independent CD8+ T
cells to initiate graft rejection, this strategy is not always effective. In this work we
demonstrate that blockade of the CD40-CD154 pathway at the time of transplantation
enables the generation of donor alloantigen-specific CD4+ CD25+ regulatory T cells, and
that if the regulatory cells are present in sufficient numbers they can suppress allograft …
Blockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in selected rodent and in primate models, but, due to the ability of CD154-independent CD8+ T cells to initiate graft rejection, this strategy is not always effective. In this work we demonstrate that blockade of the CD40-CD154 pathway at the time of transplantation enables the generation of donor alloantigen-specific CD4+ CD25+ regulatory T cells, and that if the regulatory cells are present in sufficient numbers they can suppress allograft rejection mediated by CD154-independent CD8+ T cells. The Journal of Immunology, 2002, 169: 5401–5404.
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