[HTML][HTML] Lung transplant acceptance is facilitated by early events in the graft and is associated with lymphoid neogenesis

W Li, AC Bribriesco, RG Nava, AA Brescia… - Mucosal …, 2012 - Elsevier
Early immune responses are important in shaping long-term outcomes of human lung
transplants. To examine the role of early immune responses in lung rejection and
acceptance, we developed a method to retransplant mouse lungs. Retransplantation into T-
cell-deficient hosts showed that for lungs and hearts alloimmune responses occurring within
72 h of transplantation are reversible. In contrast to hearts, a 72-h period of
immunosuppression with costimulation blockade in primary allogeneic recipients suffices to …