Long-term functional outcome data should not in general be used to guide end-of-life decision-making in the ICU

ME Wilson, RO Hopkins, SM Brown - Critical care medicine, 2019 - journals.lww.com
ME Wilson, RO Hopkins, SM Brown
Critical care medicine, 2019journals.lww.com
Physician prognostication of functional outcomes appears to be even worse than
prognostication of mortality. Among approximately 300 patients in Pennsylvania, clinician
predictions poorly discriminated functional outcomes and discriminated worse than
predictions of mortality (13). In a single-center study, over half of ICU attending physicians
recalled being surprised to discover that patients in whom they had recommended limiting
life support on the basis of anticipated poor outcomes had in fact survived, sometimes with …
Physician prognostication of functional outcomes appears to be even worse than prognostication of mortality. Among approximately 300 patients in Pennsylvania, clinician predictions poorly discriminated functional outcomes and discriminated worse than predictions of mortality (13). In a single-center study, over half of ICU attending physicians recalled being surprised to discover that patients in whom they had recommended limiting life support on the basis of anticipated poor outcomes had in fact survived, sometimes with no functional impairment (14).
Predictive models for functional outcomes are also inadequate. Acute severity of illness is not associated with functional outcomes among survivors (15). Baseline impairments dominate subsequent outcomes but are as yet inadequately characterized in clinical practice and research (16). In addition, methodological problems plague prognostic models. First, most predictive models are validated in terms of discrimination (how often, on average, nonsurvivors have higher
Lippincott Williams & Wilkins