Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells
The rise in influenza-specific neutralizing antibody levels is proceeded by a burst of antigen-
specific antibody secreting cells (ASC) or plasmablasts identified in peripheral blood
approximately 5–10 days post immunization. Blood antigen-specific ASC may function as an
immune marker of vaccine responses in comparison to the pre-and post-neutralizing titers;
however, some have questioned whether there is adequate survival of ASC isolated from
peripheral blood after freezing, making multi-center vaccine trials difficult. Here, we …
specific antibody secreting cells (ASC) or plasmablasts identified in peripheral blood
approximately 5–10 days post immunization. Blood antigen-specific ASC may function as an
immune marker of vaccine responses in comparison to the pre-and post-neutralizing titers;
however, some have questioned whether there is adequate survival of ASC isolated from
peripheral blood after freezing, making multi-center vaccine trials difficult. Here, we …