ATPase activity and conformational changes in the regulation of actin
H Schüler - Biochimica et Biophysica Acta (BBA)-Protein Structure …, 2001 - Elsevier
The eukaryotic microfilament system is regulated in part through the nucleotide-and cation-
dependent conformation of the actin molecule. In this review, recent literature on the crystal
and solution structures of actin and other actin-superfamily proteins is summarized.
Furthermore, the structure of the nucleotide binding cleft is discussed in terms of the
mechanism of ATP hydrolysis and Pi release. Two distinct domain movements are
suggested to participate in the regulation of actin.(1) High-affinity binding of Mg2+ to actin …
dependent conformation of the actin molecule. In this review, recent literature on the crystal
and solution structures of actin and other actin-superfamily proteins is summarized.
Furthermore, the structure of the nucleotide binding cleft is discussed in terms of the
mechanism of ATP hydrolysis and Pi release. Two distinct domain movements are
suggested to participate in the regulation of actin.(1) High-affinity binding of Mg2+ to actin …