Propionyl-L-carnitine is efficacious in ulcerative colitis through its action on the immune function and microvasculature
MG Scioli, MA Stasi, D Passeri, E Doldo… - Clinical and …, 2014 - journals.lww.com
OBJECTIVES: Microvascular endothelial dysfunction characterizes ulcerative colitis (UC),
the most widespread form of inflammatory bowel disease. Intestinal mucosal microvessels in
UC display aberrant expression of cell adhesion molecules (CAMs) and increased
inflammatory cell recruitment. Propionyl-L-carnitine (PLC), an ester of L-carnitine required
for the mitochondrial transport of fatty acids, ameliorates propionyl-CoA bioavailability and
reduces oxidative stress in ischemic tissues. The present study aimed to document the …
the most widespread form of inflammatory bowel disease. Intestinal mucosal microvessels in
UC display aberrant expression of cell adhesion molecules (CAMs) and increased
inflammatory cell recruitment. Propionyl-L-carnitine (PLC), an ester of L-carnitine required
for the mitochondrial transport of fatty acids, ameliorates propionyl-CoA bioavailability and
reduces oxidative stress in ischemic tissues. The present study aimed to document the …
