[HTML][HTML] Serum 25-hydroxyvitamin D concentration is inversely associated with mucosal inflammation in patients with ulcerative colitis
K Meckel, YC Li, J Lim, M Kocherginsky… - The American journal of …, 2016 - Elsevier
Background: Vitamin D exerts anti-inflammatory actions both in vitro and in murine models of
colitis. In previous studies, we demonstrated that vitamin D protects against the development
of colitis by maintaining the integrity of the intestinal mucosal barrier. Objective: We sought to
evaluate whether deficient serum 25 hydroxyvitamin D [25 (OH) D] concentrations are
associated with increased mucosal inflammation, a loss of epithelial junctional proteins, and
an increase in mucosal inflammatory cytokines in patients with ulcerative colitis (UC) …
colitis. In previous studies, we demonstrated that vitamin D protects against the development
of colitis by maintaining the integrity of the intestinal mucosal barrier. Objective: We sought to
evaluate whether deficient serum 25 hydroxyvitamin D [25 (OH) D] concentrations are
associated with increased mucosal inflammation, a loss of epithelial junctional proteins, and
an increase in mucosal inflammatory cytokines in patients with ulcerative colitis (UC) …