[HTML][HTML] erbB1 functions as a sensor of airway epithelial integrity by regulation of protein phosphatase 2A activity

PD Vermeer, L Panko, MJ Welsh, J Zabner - Journal of Biological Chemistry, 2006 - ASBMB
Two enzymes, protein phosphatase 2A and atypical protein kinase C, are associated with
the tight junction and regulate its function. For example, phosphorylation of the tight junction
protein occludin is required for its incorporation into the junction. The association of a kinase
and phosphatase with the tight junction suggests that a balance between their activities
exists and is required for normal tight junction function. This hypothesis predicts that loss of
epithelial integrity may disrupt this balance in such a way as to facilitate restoration of …