YAP and TAZ: a nexus for Hippo signaling and beyond

CG Hansen, T Moroishi, KL Guan - Trends in cell biology, 2015 - cell.com
CG Hansen, T Moroishi, KL Guan
Trends in cell biology, 2015cell.com
The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue
homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss
the function of Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding
domain (TAZ), the prime mediators of the Hippo pathway, in stem cell biology and tissue
regeneration. We highlight their activities in both the nucleus and the cytoplasm and discuss
their role as a signaling nexus and integrator of several other prominent signaling pathways …
The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss the function of Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding domain (TAZ), the prime mediators of the Hippo pathway, in stem cell biology and tissue regeneration. We highlight their activities in both the nucleus and the cytoplasm and discuss their role as a signaling nexus and integrator of several other prominent signaling pathways such as the Wnt, G protein-coupled receptor (GPCR), epidermal growth factor (EGF), bone morphogenetic protein (BMP)/transforming growth factor beta (TGFβ), and Notch pathways.
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