Increased reactive oxygen species production in epicardial adipose tissues from coronary artery disease patients is associated with brown-to-white adipocyte trans …

E Dozio, E Vianello, S Briganti… - International …, 2014 - internationaljournalofcardiology.com
Epicardial adipose tissue (EAT), a metabolically active visceral fat depot surrounding and
infiltrating myocardium and great vessels, is a recognized source of pro-inflammatory
mediators involved in the onset and development of coronary artery disease (CAD)[1–3].
EAT is made up by both white and brown adipocytes and presents the potential for trans-
differentiation from brown adipose tissue (BAT) into white adipose tissue (WAT), or vice
versa [4]. Although the secretory profile of EAT has been previously examined in patients …