EGF receptor deletion in podocytes attenuates diabetic nephropathy

J Chen, JK Chen, RC Harris - Journal of the American Society of …, 2015 - journals.lww.com
The generation of reactive oxygen species (ROS), particularly superoxide, by damaged or
dysfunctional mitochondria has been postulated to be an initiating event in the development
of diabetes complications. The glomerulus is a primary site of diabetic injury, and podocyte
injury is a classic hallmark of diabetic glomerular lesions. In streptozotocin-induced type 1
diabetes, podocyte-specific EGF receptor (EGFR) knockout mice (EGFR podKO) and their
wild-type (WT) littermates had similar levels of hyperglycemia and polyuria, but EGFR …